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Martin A Broome Selected Research

AMG 337

3/2016Discovery of (R)-6-(1-(8-Fluoro-6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)ethyl)-3-(2-methoxyethoxy)-1,6-naphthyridin-5(6H)-one (AMG 337), a Potent and Selective Inhibitor of MET with High Unbound Target Coverage and Robust In Vivo Antitumor Activity.
1/2016In Vitro and In Vivo Activity of AMG 337, a Potent and Selective MET Kinase Inhibitor, in MET-Dependent Cancer Models.

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Martin A Broome Research Topics

Disease

6Neoplasms (Cancer)
03/2016 - 05/2003
1Oncogene Addiction
01/2016
1Neoplasm Metastasis (Metastasis)
03/2015

Drug/Important Bio-Agent (IBA)

3Phosphotransferases (Kinase)IBA
03/2016 - 03/2015
2AMG 337IBA
03/2016 - 01/2016
2Pharmaceutical PreparationsIBA
03/2016 - 06/2012
2Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA
03/2016 - 06/2012
1Hepatocyte Growth Factor (Growth Factor, Hepatocyte)IBA
03/2015
1Mitogen-Activated Protein KinasesIBA
08/2010
1Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
05/2003
1EpitopesIBA
05/2003
1STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)IBA
05/2003
1AgarIBA
05/2003
1src-Family KinasesIBA
05/2003
1Focal Adhesion Protein-Tyrosine KinasesIBA
05/2003